Irinotecan (97682-44-5)
Irinotecan is a semi-synthetic water-soluble camptothecin derivative. It and its metabolite SN38 are DNA topoisomerase I inhibitors. The complex formed with topoisomerase I and DNA can cause DNA single-strand breaks, prevent DNA replication and inhibit RNA synthesis, which is cell cycle S phase specific.
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Irinotecan is a semi-synthetic water-soluble camptothecin derivative. It and its metabolite SN38 are DNA topoisomerase I inhibitors. The complex formed with topoisomerase I and DNA can cause DNA single-strand breaks, prevent DNA replication and inhibit RNA synthesis, which is cell cycle S phase specific.
Indications: It is the first-line drug for advanced colorectal cancer and can also be used for postoperative adjuvant chemotherapy; it is also effective for lung cancer, breast cancer and pancreatic cancer.
Clinical application: monotherapy, intravenous: 350mg/m per drip for 30-90 minutes, once every 3 weeks. The dosage can be reduced appropriately according to patient's specific conditions.
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