Warfarin sodium (129-06-6)

　　Warfarin sodium tablets are indicated for patients requiring long-term, continuous anticoagulation: (1) to prevent the formation and progression of thrombi, used in the treatment of thromboembolic disorders; (2) to treat venous thrombosis following surgery or trauma, and may be used as an adjunctive therapy in myocardial infarction; (3) for patients with a history of thromboembolic disease or those at risk of postoperative thrombotic complications, as prophylactic therapy.

　　Chemical name: 3-(α-Acetylbenzyl)4-hydroxycoumarin

　　Chemical structural formula:

　　Molecular formula: C19H15NaO4

　　Molecular weight: 330.31

　　Characteristics

　　This product is a sugar-coated tablet; upon removal of the coating, it appears white.

　　Usage and Dosage

　　Oral administration: In adults, the usual dosage is as follows: Avoid bolus therapy. During days 1–3, administer 3–4 mg orally (half this dose is sufficient for elderly, frail patients, and those with diabetes). After 3 days, switch to a maintenance dose of 2.5–5 mg per day (dose may be adjusted based on coagulation time to achieve an INR of 2–3). Because this drug has a slow onset of action, during the first 3 days of treatment, plasma anticoagulant proteins and cells may be suppressed, potentially leading to a transient hypercoagulable state. If immediate anticoagulation is required, heparin may be initiated concurrently; discontinue heparin once this product has fully exerted its anticoagulant effect.